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- 38Medicine and Dentistry, Faculty of/Alberta Research Centre for Health Evidence (ARCHE)
- 35Medicine and Dentistry, Faculty of/Journal Articles (Medicine and Dentistry)
- 9Oncology, Department of
- 9Oncology, Department of/Medical Physics
- 5University of Alberta Library
- 22Hartling, L.
- 17Klassen, T. P.
- 11Hartling, Lisa
- 11Schulz, Richard
- 9Babenko, Oksana
- 9De Zanche, Nicola
- 12Systematic reviews
- 10Pediatrics
- 5Child health
- 5Meta-analysis
- 5Randomized controlled trials
- 4Drug therapy
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2015/18/12
Introduction: Non-invasive ventilation (NIV) in children has become an increasingly common modality of breathing support where pressure support is delivered through a mask interface or less commonly through other non-invasive interfaces. At this time, NIV is considered a first-line option for...
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Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism
Download2013-01-01
Neto‐Neves, Evandro M., Sousa‐Santos, Ozelia, Ferraz, Karina C., Rizzi, Elen, Ceron, Carla S., Romano, Minna M., Schulz, Richard, Tanus‐Santos, Jose E.
Activated matrix metalloproteinases (MMPs) cause cardiomyocyte injury during acute pulmonary thromboembolism (APT). However, the functional consequences of this alteration are not known. We examined whether doxycycline (a MMP inhibitor) improves right ventricle function and the cardiac responses...
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Matrix metalloproteinase‐2, caveolins, focal adhesion kinase and c‐Kit in cells of the mouse myocardium
Download2007-01-01
Cho, Woo Jung, Chow, Ava K., Schulz, Richard, Daniel, Edwin E.
Matrix metalloproteinase‐2 (MMP‐2) may play roles at intracellular and extracellular sites of the heart in ischaemia/reperfusion injury. Caveolins (Cav‐1, ‐2 and ‐3) are lipid raft proteins which play roles in cell sig‐nalling. This study examined, using immunohistochemistry and two photon...
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Multicentric osteolysis with nodulosis, arthritis, and cardiac defect syndrome: loss of MMP2 leads to increased apoptosis with alteration of apoptotic regulators and caspases and embryonic lethality
Download2014-01-01
Martignetti, John A., Mosig, Rebecca A., Schulz, Richard, Kassiri, Zamaneh, Schaffler, Mitchell B.
Inactivating mutations of matrix metalloproteinase 2 (MMP2) cause multicentric osteolysis with nodulosis and arthritis, one of a group of inherited osteolytic and arthritic disorders. We have previously shown that mice lacking Mmp2 share similar syndromic features with the human disorder, and at...
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2013-02-15
Joffe, Ari, Vandermeer, Ben, Hartling, Lisa, Lequier, Laurance, Larsen, Bodil, Anton, Natalie, Tjosvold, Lisa
Background: Nutritional support in the critically ill child has not been well investigated and is a controversial topic within paediatric intensive care. There are no clear guidelines as to the best form or timing of nutrition in critically ill infants and children. Objectives: To assess the...
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2017-12-21
Kordzadeh, Atefeh, De Zanche, Nicola
This is a post-peer-review, pre-copyedit version of an article published in Magnetic Resonance in Medicine. The final authenticated version is available online at: https://doi.org/10.1016/j.mri.2017.12.016 Placing dielectric pads adjacent to the imaging region is an effective method to increase...
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Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials.
Download2004
Klassen, T. P., McConnell, D., Craig, W. R., Wiebe, N., Hartling, L., Bellemare, S., Russell, K.
Background Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries. We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy...
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2016-01-13
Kordzadeh, Atefeh, De Zanche, Nicola
This is the peer reviewed version of the following article: Concepts Magn Reson Part B (Magn Reson Engineering) 46B: 19–24, 2016, which has been published in final form at https://doi.org/10.1002/cmr.b.21318. This article may be used for non-commercial purposes in accordance with Wiley Terms and...
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Phosphorylation status of 72 kDa MMP-2 determines its structure and activity in response to peroxynitrite
Download2013-01-01
Jacob-Ferreira, Anna Laura, Kondo, Marcia Yuri, Baral, Pravas Kumar, James, Michael N., Holt, Andrew, Fan, Xiaohu, Schulz, Richard
Matrix metalloproteinase-2 (MMP-2) is a key intra- and extra-cellular protease which contributes to several oxidative stress related pathologies. A molecular understanding of 72 kDa MMP-2 activity, directly mediated by S-glutathiolation of its cysteine residues in the presence of peroxynitrite...