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Skip to Search Results- 69Klassen, John S.
- 52Kitova, Elena N.
- 17Serpe, Michael J.
- 13Macauley, Matthew S.
- 12Liu, Lan
- 10El-Hawiet, Amr
- 20Electrospray ionization mass spectrometry
- 12Affinity
- 11Complexes
- 10Carbohydrates
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Synthesis of the Campylobacter jejuni 81-176 strain capsular polysaccharide repeating unit reveals the absolute configuration of its O-methyl phosphoramidate motif
Download2019-01-30
V. Narasimharao Thota, Michael J. Ferguson, Ryan P. Sweeney, Todd L. Lowary
The O-methyl phosphoramidate (MeOPN) motif is a non-stoichiometric modification of capsular polysaccharides (CPS) in ~70% of all Campylobacter jejuni strains. Infections by C. jejuni lead to food-borne illnesses and the CPS they produce are key virulence factors. The MeOPN phosphorus atom in...
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2019-01-31
Chlorella viruses produce N-linked glycoproteins with carbohydrate moieties that differ in structure from all other N- linked glycans. In addition, unlike most viruses, these organisms do not hijack the biosynthetic machinery of the host to make glycocoproteins; instead, they produce their own...
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Synthetic Polyprenol-Pyrophosphate Linked Oligosaccharides Are Efficient Substrates for Mycobacterial Galactan Biosynthetic Enzymes
Download2019-01-31
Xiaochao Xue, Ruixiang Blake Zheng, Akihiko Koizumi, Ling Han, John S. Klassen, Todd L. Lowary
Mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce a complex cell wall that is critical for their survival. The largest structural component of the cell wall, the mycolylarabinogalactanpeptidoglycan complex, has at its core a galactan domain composed of...
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2014
Marcondes, Maria C. G., Macauley, Matthew S., Pang, Poh-Choo, Bortell, Nikki, Arlian, Britni M., Rillahan, Cory D., Haslam, Stuart M., Dell, Anne , Paulson, James C.
Sialic acid terminates glycans of glycoproteins and glycolipids that play numerous biological roles in health and disease. Although genetic tools are available for interrogating the effects of decreased or abolished sialoside expression in mice, pharmacological inhibition of the sialyltransferase...
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Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation
2014
Macauley, M. S., Cheng, T. Y., Moody, D. B., Paulson, J. C. , Kawasaki, N., Van Rhijn, I., Rillahan, C. D.
Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are activated by lipid Ags presented by myeloid dendritic cells (DCs), after which they generate antibacterial effector functions, including...
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2016
O’Dwyer, Michael E., Macauley, Matthew S., Natoni, Alessandro
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and...
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2022-01-01
Cyclic tetraaryl[5]cumulenes (1a–f) have been synthesized and studied as a function of increasing ring strain. The magnitude of ring strain is approximated by the extent of bending of the cumulenic core as assessed by a combination of X-ray crystallographic analysis and DFT calculations. Trends...
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The influence of temperature on the pyrolysis of household products
2016-01-01
Xiao Qin Lee, P. Mark L. Sandercock, James J. Harynuk
We have previously demonstrated the successful application of multivariate statistical(i.e. chemometric) techniques to the classification of casework fire debris based on gasoline content, with the objective to expedite the data interpretation process for the forensic analysis of fire debris. We...
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Thermal dissociation of streptavidin homotetramer in the gas phase: Subunit loss versus backbone fragmentation
Download2013
Deng, Lu, Klassen, John S., Kitova, Elena N., Sinelnikov, Igor
The results of time-resolved blackbody infrared radiative dissociation experiments performed on gaseous protonated ions, at charge states +15, +16 and +17, of the homotetramer streptavidin (S4) are reported. Evidence is found for three dissociation pathways involving (i) the loss of a single...
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Thermal dissociation of streptavidin homotetramer in the gas phase: Subunit loss versus backbone fragmentation
Download2013
Klassen, John S., Sinelnikov, Igor, Kitova, Elena N., Deng, Lu
The results of time-resolved blackbody infrared radiative dissociation experiments performed on gaseous protonated ions, at charge states +15, +16 and +17, of the homotetramer streptavidin (S4) are reported. Evidence is found for three dissociation pathways involving (i) the loss of a single...