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- 1Acute lymphoblastic leukemia
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- 1Childhood cancer
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Fall 2018
As medical care in developed countries has become increasingly specialized, health care resources by necessity have become more regionalized. The assessment and management of critical illness and injury in infants and children require specialized training and experience. To improve patient care...
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From G551D to F508del: An Inquiry Into The Development Of Targeted Therapeutics For The Treatment Of Cystic Fibrosis
DownloadFall 2016
Cystic Fibrosis (CF) is a fatal inherited disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Regulator (CFTR) protein. CFTR plays an integral role in salt and water transport across the epithelial membrane of major organs, such as the lungs. CFTR-targeted...
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Inequalities by Race/Ethnicity and Socioeconomic Position in the Incidence and Survival of Childhood Acute Lymphoblastic Leukemia in the United States
DownloadFall 2015
Background: Childhood acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the United States. The incidence and survival of childhood ALL have been reported to be closely associated with race/ethnicity and socioeconomic position (SEP). However, the relationship between SEP...
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Looking beyond the standard genome-wide association study: Biologically-motivated methodological approaches to discover novel genetic variants associated with complex human traits and disease
DownloadFall 2018
The standard approach for testing associations between common single nucleotide genetic variants (referred to as single nucleotide polymorphisms or SNPs) and disease entails testing disease associations for each SNP in the genome individually. This “hypothesis-free” approach has identified...
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Public Health Applications Using Big Data and Machine Learning Methods: Name- and Location-based Aboriginal Ethnicity Classification and Sentiment Analysis of Breast Cancer Screening in the United States Using Twitter
DownloadFall 2017
Applications using big data and machine learning techniques are transforming how people live in the 21st century, however they are generally underutilized in public health compared to other domains. We proposed and conducted two independent studies to investigate how big data and machine learning...
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Statistical Learning with Many Variables as Covariates or Outcomes: Association Inference and Prediction of Late effects of Childhood Cancer and Its Treatment
DownloadSpring 2024
Advancements in childhood cancer treatment have increased the 5-year survival rates substantially, from 20% in 1950-1954 to over 85% currently. While this success is a remarkable accomplishment in oncology, it concurrently introduces a new concern, namely, the emergence of late adverse effects,...