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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
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Imaging the hemodynamics of pial collaterals and evaluating collateral therapeutics in rodent models of acute ischemic stroke
DownloadFall 2019
Ischemic stroke is caused by blockage of a primary blood vessel supplying brain tissue. Cerebral collaterals are auxiliary vascular pathways in the cerebral circulation that can provide residual blood flow to partially maintain perfusion in ischemic tissue when primary vascular routes are...
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Integrating Characteristics of Executive Functions in Non-Demented Aging: Structure, Trajectories, Classification, and Biomarker Predictors
DownloadSpring 2019
In aging, executive function (EF) performance (level) and change (trajectory) are linked to multiple interacting risk factors. Structurally, EFs have previously been represented as either a unitary (e.g., unidimensional) or diverse (e.g., multidimensional) set of abilities that change across the...
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Intermittent Electrical Stimulation as a Treatment Approach for Deep Tissue Pressure Injury after a Spinal Cord Injury
DownloadFall 2018
The goal of this study was to investigate the effects and mechanisms of action of an intermittent electrical stimulation (IES) paradigm on the healing of deep-seated muscle injury. Electrical stimulation has been extensively studied for the treatment of open wounds, often with amplitudes lower...
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 T
DownloadFall 2020
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...
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Investigating Mechanisms Responsible for the Pro-Regenerative Effects of Conditioning Electrical Stimulation
DownloadFall 2022
Though capable of regeneration, repair surgeries following peripheral nerve injury are often incomplete or entirely unsuccessful. The slow rate of regeneration (1-3mm/day) of a proximal injury requires up to two years to reach the distal target, whereas significant muscle atrophy occurs after...
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Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
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Fall 2019
Acquisition and storage of episodic-like information fundamentally contributes to quality of life. It is the type of information that allows us to remember meaningful events such as our graduation and our heartaches. The memory of these events allows us to adapt our behaviours to facilitate more...
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Fall 2021
Intraspinal microstimulation (ISMS) is a neural prosthetic technique which can restore locomotor function in models of severe spinal cord injury (SCI). Historically, ISMS has been implemented with microwire electrodes or rigid multielectrodes, which suffer from limitations related to either...
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Locomotion-related propriospinal V3 interneurons modulate sensory-transmission to motoneurons by generating primary afferent depolarization
DownloadFall 2022
Proprioceptive sensory-evoked reflexes are essential in assisting the precision of basic movements and maintenance of body postures. The motor outputs from these reflexes are precisely calibrated to avoid interfering with the ongoing motor functions. After spinal cord injury (SCI), reflexes...