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- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
A novel non-viral knockdown strategy targeting retinoblastoma protein for regeneration of peripheral axonsDownload
Peripheral nerve degeneration as a result of traumatic nerve injury is a common neurological condition that is characterized by varying degrees of sensory, autonomic, and motor dysfunction. Due to the high prevalence of peripheral nerve damage, there is a pressing need to develop novel therapies...
The reason and functional relevance of why we sleep continues to perplex researchers. One fundamental reason behind why sleep remains a mystery is because it is challenging to study given how easily it is disrupted. Anesthesia has been suggested to be a model for studying sleep given the...
Alteration of astrocyte markers and phosphorylation of tau protein in kainic acid-treated animal model of Temporal Lobe EpilepsyDownload
Kainic acid, an analogue of the excitatory neurotransmitter glutamate, when administered systemically can trigger seizures and neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (mTLE), which affects ~50million people globally. Evidence suggests that...
An exploration of neural network activity within the limb-associated somatosensory cortex of the healthy and stroke injured brain of miceDownload
Altered somatosensation is a hallmark of incomplete recovery from stroke. Although the basic mechanisms of limb-associated somatosensation have been well studied in primates, comparatively little literature exists on the limb-associated somatosensory system of rodents. Rodent models are the...
Associations between Frontoparietal and Temporal White Matter, Neurocognitive Abilities and Age in Children and Youth with Prenatal Alcohol ExposureDownload
Prenatal alcohol exposure (PAE) has been linked to neurological, behavioural, cognitive, and emotional problems. The neurocognitive impairments identified in individuals with PAE are prevalent and have a major impact on the quality of life of individuals living with the effects of PAE....
Covert awareness is difficult to detect in patients with cognitive-motor dissociation after severe neurological injury. In order to avoid over-reliance on subjective measures which are error prone, neurological evaluations must include behaviour-based ratings and objective, technology-based...
This thesis investigates how to bolster activity dependent neuronal plasticity in conjunction with rehabilitative motor therapy to increase recovery following spinal cord injury in rats. My work focuses primarily on the injured corticospinal tract (CST) and how boosting intracellular signalling...
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
Activation of α5 GABAA receptors located on nodes of primary afferents have been found to produce a long lasting tonic primary afferent depolarization in the spinal cord (tonic PAD). In particular, C fibres have been found to be especially effective in eliciting this tonic PAD. Here by activating...
Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzineDownload
Multiple sclerosis (MS) is a chronic, progressive disease that involves neuroinflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While loss of motor function and paralysis are considered the primary clinical consequences of MS, the disease is also...