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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
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Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzine
DownloadFall 2017
Multiple sclerosis (MS) is a chronic, progressive disease that involves neuroinflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While loss of motor function and paralysis are considered the primary clinical consequences of MS, the disease is also...
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Characterization of WT1-expressing interneurons and investigation of their role in locomotion
DownloadFall 2019
Mammalian locomotion is controlled by a specialized neural network, known as the locomotor central pattern generator (CPG), which is situated entirely within the ventral spinal cord. A number of studies completed over the past two decades have indicated that this neural network is comprised of...
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Characterizing Cerebral Degeneration in Amyotrophic Lateral Sclerosis with Texture Analysis
DownloadFall 2020
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is hallmarked by unrelenting and progressive wasting and paralysis of voluntary muscles. The classic pathology in ALS features neuronal loss, gliosis, and abnormal protein deposition in the upper and lower motor neurons (UMN...
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Chronic Pain in a Mouse Model of Multiple Sclerosis: Contributions of the Kappa Opioid System
DownloadFall 2021
The perception of pain is a multimodal experience that is encoded by regions of the central nervous system (CNS) that are involved in sensation, affect, and cognition. Chronic pain is not merely the persistence of pain, but a debilitating condition that is associated with neurochemical...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...
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Concussion-Related Knowledge and Patterns of Practice in Ontario General and Family Practice and Sport and Exercise Medicine Physicians
DownloadFall 2022
Objectives: To characterize concussion knowledge levels, patterns of practice and learning preferences for physicians within the Sections of General & Family Practice (GFP) and Sport and Exercise Medicine (SEM) of the Ontario Medical Association (OMA).Methods: Cross-sectional online survey, first...
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Contraction fatigue and motor unit overlap in the tibialis anterior during different intensities of interleaved electrical stimulation
DownloadSpring 2018
Interleaved neuromuscular electrical stimulation (iNMES), which involves alternating stimulus pulses between a nerve (nNMES) and muscle belly (mNMES), has been demonstrated to reduce fatigue of the ankle dorsiflexors when used with relatively low contraction amplitudes. However, the amount of...
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Contributions of Prefrontal White Matter Integrity to Cognitive Performance in Healthy Aging
DownloadFall 2021
Aging is well-known to produce changes in the brain at both the functional and anatomical level. Increased age is associated with general brain atrophy and a decline in cognitive abilities such as executive functioning, working memory, and processing speed. A key brain region responsible for...
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Fall 2022
Ia afferents conveying proprioceptive information to the spinal cord, and the regulation of action potential conduction along these afferents, are vital for motor function. After injury to the central nervous system (CNS), hyperexcitability in proprioceptive and other afferent pathways to the...
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Decreases in the excitability of motor axons contribute substantially to contraction fatigability during neuromuscular electrical stimulation
DownloadFall 2017
Activity-dependent changes in axonal excitability are well-documented, yet the contribution to contraction fatigability during neuromuscular electrical stimulation (NMES) is unclear. The present study was designed to: 1) characterize the magnitude and time course of changes in motor axon...