Search
Skip to Search Results- 1 Lansing, Marihan
- 1Abu Alrub, Osama Y
- 1Ahrari, Malema
- 1Ali, Amber Z
- 1Ali, Noureen
- 1Allan, Chantal J
-
Spring 2013
Background: Bias is a significant concern in pediatric randomized controlled trials (RCTs), but while there have been numerous calls for improvement in trial conduct, traditional means of education and dissemination of methodological principles have not had a substantial effect on the quality of...
-
Let’s get physical: Aerobic capacity, muscle strength, and muscle endurance in pediatric transplant recipients
DownloadFall 2018
Pediatric heart and kidney transplant recipients appear to have lower physical fitness than healthy children. This study sought to quantify the fitness level of transplant recipients and investigate clinical and lifestyle factors that may affect physical fitness. First, a systematic review and...
-
Fall 2023
The Developmental Origins of Health and Disease (DOHaD) theory posits that insults during critical developmental periods can cause permanent structural and functional changes in key organ systems and thereby predispose an individual to chronic disease later in life. During gestation, iron...
-
Spring 2012
Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) remain a major health issue because of a high mortality and morbidity rate. Despite progress in understanding the pathogenesis of ALI, there is currently no drug-based therapy promoting lung repair. A predominant pathological...
-
Mapping Congenital Heart Disease and the Emission of Developmental Toxicants in Alberta, Canada: A Geographic Information System Based Framework for Supporting Interdisciplinary Research and Surveillance Monitoring
DownloadFall 2018
Background: Congenital heart disease (CHD) is a significant global public health issue affecting 1% of all live births and the most common lethal congenital abnormality in infancy. Although CHD may occur in the presence of chromosomal abnormalities, in most affected children, the cause is...
-
Spring 2014
Chronic trauma in childhood can program an abnormal stress reaction, resulting in lifelong difficulties with stress management and poor health outcomes linked to changes in the immune system. At the same time, maternal stress during pregnancy has been linked to childhood asthma. Given the...
-
Maternal Overweight Prior to Pregnancy and its Impact on the Infant Gut Microbiome and Subsequent Child Overweight Risk
DownloadSpring 2015
Background: Maternal overweight and obesity is a widespread problem in Canada that has been linked to many complications during pregnancy. The gut microbiome has been revealed to have origins during infancy, which might be influenced by maternal weight gain during pregnancy. It would be...
-
Spring 2019
Dramatic maturational changes occur in heart energy metabolism in the fetal to newborn transition, most predominantly marked by a decrease in glycolysis and an increase in fatty acid oxidation which then becomes the major energy providing substrate for the heart after birth. However, in the...
-
Measurement properties of primary outcome measures in pediatric RCTs: inadequate reporting, insufficient validation, or both?
DownloadFall 2013
Randomized controlled trials (RCTs) are the gold standard for high quality evidence generation pertaining to treatment effectiveness. RCT results are used in knowledge synthesis and evidence-based practice. The validity of RCT results is dependent upon the validity of the primary outcome...
-
Mechanisms of Neonatal Intestinal Failure-Associated Liver Disease: Exploring the Gut-Liver Axis
DownloadSpring 2018
Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....