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Maternal Overweight Prior to Pregnancy and its Impact on the Infant Gut Microbiome and Subsequent Child Overweight Risk
DownloadSpring 2015
Background: Maternal overweight and obesity is a widespread problem in Canada that has been linked to many complications during pregnancy. The gut microbiome has been revealed to have origins during infancy, which might be influenced by maternal weight gain during pregnancy. It would be...
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Pre and postnatal maternal distress and infant gut immunity in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort
DownloadSpring 2017
Introduction: Secretory immunoglobulin A (sIgA) plays a critical role in gut mucosal immunity and is a marker of immune maturation in early life. Delayed IgA production is associated with increased risk of allergic diseases. Animal models of stressful events before birth and during infancy show...
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Sleep Duration and the Gut Microbiota in Infancy: an exploration of the determinants of sleep and the association between sleep and the gut microbiota at 3 months of age in a Canadian birth cohort
DownloadSpring 2019
RATIONALESleep duration is critical to growth, cognitive development, and overall health status in infancy. Strategies to ensure that national recommendations for sleep duration in infants are met require knowledge of perinatal factors that affect infant sleep. Parental socioeconomic status...
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....