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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of ResistanceDownload
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
Development of the vertebrate ocular structures requires the cooperative interactions of transcription factors, signalling proteins, external growth factors, and epigenetic regulatory factors. Consequently, misregulation of these cues can result in a number of developmental and functional...
Investigating 14-3-3 Protein Subcellular Localization, Colocalization with Subcellular Markers and Interaction with Rac1Download
14-3-3 proteins are a group of widely expressed, highly conserved homo/heterodimeric acidic proteins. They usually bind to serine/threonine phosphorylated proteins, but also bind to proteins in a phosphorylation-independent manner. 14-3-3 proteins have over 200 binding partners. 14-3-3 proteins...
Non-Synonymous Variants in the Premelanosome Protein (PMEL) Gene are Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Cause Biochemical DefectsDownload
Pigmentary Glaucoma (PG) is a common glaucoma subtype that results from release of pigment from the iris (Pigment Dispersion Syndrome) and its deposition throughout the anterior chamber of the eye. Although PG has a substantial heritable component, no causative gene variants have yet been...
REGULATION OF THE BMI1 AND RET PROTO-ONCOGENES BY THE DLX2 TRANSCRIPTION FACTOR IN THE DEVELOPING GASTRO-INTESTINAL TRACTDownload
The Dlx1/Dlx2 double knockout (DKO) mouse dies at P0 with a cleft palate and a distended abdomen. Within the intestinal crypts of Leiberkuhn a stable, non-dividing stem cell group is marked by the oncogene BMI1. Unpublished data from the Eisenstat laboratory demonstrates co-expression of BMI1 and...
EGFR-mediated signaling has been studied extensively since the 1980s due to its importance in several types of cancers. The majority of the research however has focused on the actions of the EGFR during G0/G1 and has neglected to characterize EGFR outside of this cell cycle phase. In this thesis,...