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Skip to Search Results- 1Al-Hallak, MHD Kamal
- 1Alarifi, Saqer
- 1Almukainzi, May
- 1Almukainzi, May Khalifah
- 1Alshikhey,Areej
- 1Amaral Silva, Daniela
- 4Dissolution
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- 2Lung cancer
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- 1Anti-apoptotic proteins
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Repositioning study of flubendazole for treating lung cancer and meningoencephalitis using an oral lipid nanosystem
DownloadFall 2023
Nanoemulsions have wide application, presenting several properties such as the solubilization of poorly soluble drugs in water, promoting the increase of their bioavailability, allowing greater stability of the formulation and, due to its property as a carrier, promoting their modified release....
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Studies on antimicrobial and antioxidant properties of phosvitin hydrolysates produced by high hydrostatic pressure combined with enzymatic hydrolysis
DownloadFall 2016
Phosvitin (PV) is a metal binding protein in egg yolk with unique amino acid composition (more than 55% serine). Due to a high proportion of phosphorylated serine residues, PV shows metal chelating, antioxidant and antimicrobial activities. The use of PV, however, in nutra- or pharmaceutical...
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Development of Novel Models to Study Sub and Post Cellular Uptake of Drugs Following Oral Administration
DownloadFall 2024
Given the numerous benefits of oral administration, this thesis investigates two key phenomena influencing the pharmacokinetics and pharmacodynamics of orally administered active pharmaceutical ingredients (APIs): lysosomal trapping and intestinal lymphatic uptake via chylomicrons, with a...
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Novel Biopharmaceutical Development Investigations Towards Drug and Formulation Performance Optimization
DownloadFall 2021
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of...
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Spring 2019
Breast cancer is the second most common cancer in women, and the leading cause of cancer-related deaths among women. Conventional breast cancer therapeutic strategies such as surgical removal of tumor, radiation therapy and chemotherapy have several limitations and non-specific effects on...
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Fall 2016
Macrophages are the primary cells of innate immunity that provide the first line of defence against any external stimuli. Their phagocytic properties enable them to engulf invading microbes or foreign particles. The phagocytic capability of macrophages plays a major role in interfering with drug...
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Fall 2013
Dengue virus infections can result in a range of clinical manifestations from asymptomatic infection to dengue fever and the severe disease dengue haemorrhagic fever/dengue shock syndrome. The disease is now endemic in more than 100 countries in Africa, the Americas, the eastern Mediterranean,...