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Skip to Search Results- 366Faculty of Pharmacy and Pharmaceutical Sciences
- 4Faculty of Medicine
- 2Faculty of Medicine and Oral Health Sciences
- 1Department of Biomedical Engineering
- 1Department of Medical Sciences
- 1Department of Medicine
- 1AL Omair, Omar Abdulrahman
- 1AL-AGILI, MARWA
- 1Abdelmoneim, AS
- 1Abdulsalam Alharbi
- 1Abdussalam, Ali MA
- 1Abed,Hadeel
- 15Pharmacokinetics
- 8Cytochrome P450
- 6Cancer
- 6Monoclonal antibodies
- 6Polymeric micelles
- 5Arachidonic acid
- 8El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 6El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 6Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 5Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 5Yuksel, Nese (Faculty of Pharmacy and Pharmaceutical Sciences)
- 4Doschak, Michael (Pharmacy and Pharmaceutical Sciences)
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The application of computer simulation to investigate drug absorption and bioavailability in disease states
DownloadFall 2015
Oral drug absorption relies mainly on the physicochemical drug properties and the interaction with the physiological environment of the body. These factors could be altered significantly under abnormal conditions and disease states. Identifying these changes can optimize drug therapy under these...
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The Cardioprotective Role of the N-3 PUFA Metabolite 19,20-Epoxydocosapentaenoic Acid (19,20-EDP) in the Setting of Ischemia Reperfusion Injury
DownloadSpring 2022
Ischemic heart disease (IHD) is a leading cause of cardiovascular morbidity and mortality worldwide. Myocardial ischemia occurs when a coronary artery is occluded and consequently blood supply to the heart is restricted depleting it of oxygen and nutrients. Although early myocardial reperfusion,...
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The Dissolution Behavior of Ibuprofen and Griseofulvin in Bicarbonate Buffer Compared to Phosphate Buffer Using Intrinsic Dissolution Rate and Biphasic Dissolution
DownloadFall 2018
In the small intestine, bicarbonate is the main buffering system to adjust the pH after the gastric emptying to pH 5.5-6.8. Bicarbonate gathered some attention to be used as a dissolution media to better mimic the in-vivo environment. However, in vitro the evaporation of CO2(g) interferes with...
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The effect of fluconazole on cytochrome P450 1B1, formation of arachidonic acid metabolites, and protection against angiotensin II-induced cardiac hypertrophy
DownloadFall 2018
Several studies have elucidated the role of cytochrome P450s (CYPs) and their associated arachidonic acid (AA) metabolites in development of cardiac hypertrophy. CYP1B1 has been reported to have a major role in metabolizing AA into cardiotoxic metabolites, mid-chain hydroxyeicosatetraenoic acid...
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Fall 2016
Background: The cancer stem cell (CSC) theory suggests there are small populations of cancer cells that has stem cell-like characteristics, such as self-renewal. These CSCs are thought to be responsible for initiating new tumors following metastasis. Platelets have also been implicated in cancer...