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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Fall 2010
Insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a single trans-membrane glycoprotein that is widely but selectively distributed throughout the central nervous system (CNS). IGF-II/M6P receptor is involved in the trafficking of M6P-containing lysosomal enzymes from the...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Self-Report Measures and Mobile Applications for Mental Health – Focusing on Suicidality and Bipolar Disorder – Including App Development and Measure Validation
DownloadFall 2020
This thesis describes studies evaluating the predictive validity of suicide risk assessments, assessment and monitoring of bipolar disorder using mobile app-based self-report questionnaires, the feasibility and criterion validity of novel tools for the evaluation of suicidal ideation and...
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Social Stigma Perceived by Patients with Chronic Pain Attending a Cognitive Behavioral Pain Management Program (Pain 101)
DownloadSpring 2012
There are limited data on the stigma perceived by patients with chronic pain and there are no data on the effect of cognitive behavior therapy (CBT) on stigma in chronic pain patients. The purpose of this study was to examine perceived stigma in adults with chronic pain and the effects of a...
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Spatiotemporal characterization of post-stroke myelin density changes and their contribution to functional recovery using a novel label-free in vivo imaging technique
DownloadSpring 2020
Myelin is an essential component of nervous system functioning: it supports axonal metabolism, enables saltatory conduction to allow for precise timing across cortical networks to regulate information processing and is increasingly recognized as an integral type of adult experience-dependent...
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Fall 2019
Stories matter deeply. They help us see, experience, understand, and make meaning in our world and lives. As we will see in this dissertation, to create lasting positive social change, we need new stories, stories that reveal new paths, hopes, and futures. Art is a powerful storytelling medium,...
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The Antidepressant/Antipanic/Neuroprotective Drug Phenelzine: Neuropharmacological and Drug Metabolism Studies
DownloadSpring 2013
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic and neuroprotective properties. Metabolites of PLZ were investigated in rat brain. Levels of phenylacetic acid (PAA) and β-phenylethylamine (PEA) were found to be elevated after administration of PLZ and PEH...