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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 4Baldwin, Troy (Medical Microbiology and Immunology)
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Spring 2020
Respiratory syncytial virus (RSV) is a ubiquitous respiratory pathogen that infects almost everyone by the age of two. In high-risk populations, such as infants and elderly individuals, RSV can infect the lower respiratory tract and cause severe symptoms, such as bronchiolitis or pneumonia. As a...
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Fall 2023
The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier against environmental factors, including microbial...
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Intracellular expression of Fas Ligand and Granzyme B by tumor infiltrating or in vitro activated CD8+ T cell populations
DownloadSpring 2019
CD8+ T cells can recognize infected or cancerous cells and eliminate them by exocytosing cytolytic molecules or presenting death ligands on their surface, both of which can initiate apoptosis in target cells. Granzyme B (GzmB) and Fas Ligand (FasL) are two of the effector proteins that CD8+ T...
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Investigating and characterizing the direct binding interactions between chemotherapeutic cisplatin and pattern recognition receptor, Toll-like Receptor 4
DownloadFall 2022
Cisplatin is one of the most effective chemotherapeutic agents available. Unfortunately, adverse drug reactions - cisplatin-induced toxicities - often limit the use of cisplatin. These toxicities develop in at least half of those treated, are diverse, and are especially problematic for pediatric...
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Investigating barriers to vaccinia virus recombination using combinations of light and electron microscopy
DownloadSpring 2020
While DNA viruses typically replicate in the nucleus of the host cell, poxvirus replication occurs exclusively within cytoplasmic structures known as viral factories. Viral factories are the sites of various processes of the vaccinia virus (VACV) life cycle including replication, morphogenesis...
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Spring 2013
The activation of caspases is an important step not only in apoptosis induction, but in cellular processes such as proliferation, differentiation, and the immune response. Here, we show that the AP-1 family transcription factor JunB is cleaved and dephosphorylated in a caspase-dependent manner in...
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Investigating the differential effects of LILRB1 natural variants on interaction with MHC-I and UL18
DownloadFall 2022
The Leukocyte immunoglobulin-like receptor B1 (LILRB1) is widely expressed throughout human immune cells of lymphoid and myeloid origins. It is also associated with viral infection, autoimmune diseases and cancer. LILRB1 regulates immune responses through broad interaction with major...
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Investigating the Functional Consequences of the Interaction Between Engineered Ubiquitin Variants and the Salmonella Novel E3 Ligase SspH1
DownloadFall 2024
During infection some pathogenic gram-negative bacteria, such as Salmonella, manipulate the host ubiquitination system through the delivery of secreted effectors known as novel E3 ubiquitin ligases (NELs). Despite the presence of NELs amongst these well-studied bacterial species, their unique...