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Skip to Search Results- 33Mass-spectrometry
- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Investigations of Fungal Highly Reducing Polyketide Synthases: The Biosyntheses of Lovastatin and Hypothemycin
DownloadFall 2017
Fungal highly reducing polyketide synthases (HR-PKSs) are large, multi-domain enzymes central to the biosynthesis of fungal polyketides. They assemble complex secondary metabolites, called polyketides, through the condensation of two-carbon acetate units and tailoring of the functional groups at...
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Isolation of Reactive Bonding Environments in the Main Group via New Donor-Acceptor and Kinetic Stabilization Pathways
DownloadSpring 2013
The research presented in this Thesis is focused on the synthesis of highly reactive molecules featuring Group 14 elements with the aim of discovering new bonding environments which can be translated into new forms of reactivity. Kinetic stabilization with the use of sterically demanding ligands...
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Fall 2018
The detection of specific proteins and deoxyribonucleic acid (DNA) can be used for disease diagnostics, pathogen identification, and the study of biological processes. Many proteins and nucleic acids occur at low concentrations, making their detection challenging. The detection of trace-level DNA...
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Isotope Labeling Liquid Chromatography Mass Spectrometry: Metabolite Identification and Human Salivary Metabolome Profiling
DownloadFall 2012
The objective of this work was to use paired labeling reagents that are chemically identical but isotopically different to provide a simple and robust way of mass spectrometry (MS)-based metabolome profiling. A differential 13C-/12C-isotope dansyl chloride (DnsCl) derivatization strategy has been...