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Skip to Search Results- 33Mass-spectrometry
- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Fall 2023
Alzheimer’s disease (AD) is a common neurodegenerative dementia, and its pathological hallmarks include amyloid-β plaque and neurofibrillary tangle formation in the brain. Genome-wide association studies (GWAS) revealed that a rare single nucleotide polymorphism (SNP) in CD33 is associated with...
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Biochemical investigations of two polyketide synthase subclasses – highly reducing/non-reducing pairs, and polyketide synthase non-ribosomal peptide synthetases.
DownloadSpring 2016
Cladosporin is a polyketide metabolite that is biosynthesized by a highly reducing (HR)/non-reducing (NR) polyketide synthase (PKS) pair, wherein they catalyse head-totail condensation of acetyl and malonyl CoA units with subsequent β-keto modification. Cladosporin has recently been reported as a...
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Fall 2023
Biomass burning, from wildfires to cooking stoves, is a major contributor to atmospheric pollution on a global scale, affecting the quality of the air we breathe. Emissions from biomass burning are both health and climate affecting, and vary considerably in composition depending on how the fuel...
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Spring 2017
Nanomaterials have been widely involved in biomolecular analysis, to refine traditional analytical method or develop complementary techniques. In this thesis, nanoporous structures were utilized in two applications, DNA electrophoresis and solid matrix laser desorption ionization (SMALDI)....
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Biosynthetic Studies of Resorcylic Acid Lactones, Hypothemycin, Radicicol, and Dehydrocurvularin
DownloadFall 2013
Fungal polyketides, a vast source for pharmaceutical industries, are biosynthesized by multifunctional iterative polyketide synthases (PKS). The biosynthesis employs complex programming rules, which are currently unresolved. To decode the programming rules, the biosynthesis of three polyketides,...