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Skip to Search Results- 33Mass-spectrometry
- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Generation and Trapping of Highly Strained Reactive Intermediate: Ethyl 1,2-Cyclohexadienecarboxylate
DownloadFall 2015
Highly strained reactive intermediates can initiate chemical reactions and afford unique products. Cyclic allenes are important examples of such intermediates. Within the cyclic allene family, 1,2-cyclohexadiene was intensively studied over the years. In this dissertation, the investigation of...
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Spring 2022
Phage display libraries bearing natural amino acids are commonly used for discovering potential therapeutic macrocycles; however, direct application of those linear peptides often leads to poor pharmacokinetics, including low serum stability, lower cell membrane permeability, and rapid renal...
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Genetically encoded fluorescent biosensors for detection of ligands and protein-protein interactions
DownloadSpring 2021
Fluorescence imaging enables direct visualization of cellular activities with remarkable resolutions supported by advancing technologies. The fluorescent markers for biomolecules complement the hardware and software for imaging a specific target in detail. Genetically encoded fluorescent proteins...
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Fall 2019
Genetically-encoded fragment-based discovery (GE-FBD) holds the promise for accelerate ligand discovery for protein targets. By chemical bridging of readily available genetically encoded (GE) libraries of polypeptides with constant fragments, this methodology opens a fast route to discover...
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Spring 2016
Carbohydrates play vital roles in many disease pathologies, including inflammatory disease, cancer metastasis, autoimmune disease and pathogenic infection. Despite their significance and immense opportunity for pharmaceutical application, carbohydrate-derived drugs only constitute a relatively...