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Skip to Search Results- 33Mass-spectrometry
- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Spring 2018
A series of phosphoranimide-supported first-row transition metal clusters were prepared, structurally characterized, and investigated for catalytic hydrogenolysis of carbon-heteroatom bonds. Homoleptic heterocubane clusters, as well as two-dimensional bi- and tetranuclear compounds of manganese,...
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First-Row Transition Metal-Mediated Reactions: Catalytic Ester Hydrogenolysis, Aerobic Alkane Oxidation, and [5+2] Ring-Expansion Reactions
DownloadSpring 2014
The research described in this dissertation focuses on first-row transition metal catalyzed and mediated organic reactions. The first part of the thesis involves the exploration of the catalytic reactivity of phosphoranimide-supported tetrametallic nickel and cobalt clusters, while the second...
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Spring 2012
In this thesis, we develop a sensitive, robust, accurate method to detect chemically-induced DNA damage by three therapeutic agents, cisplatin, psoralen and busulfan. The method uses fluorescence spectroscopy and fluorescent hairpin or molecular beacon probes in a hybridization assay for...
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Fluorogenic and fluorescent bioorthogonal labelling strategies for examining glycoproteins and phospholipids
DownloadFall 2012
Traditional genetically-encoded imaging strategies are problematic for use in analysing cell surface interactions due to the heterogeneous nature of the cell surface, and the high level of post-translational modifications. Small molecule fluorophores can provide dynamic information on cell...
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Formal radical cyclization onto aromatic rings, cascade intramolecular conjugate displacement and synthetic studies on marinopyrroles
DownloadFall 2011
The first chapter of this thesis describes the development of a general method for indirectly effecting radical carbocyclization of an alkyl chain onto an aromatic ring. This process involves a Birch reductive alkylation of aromatic tert-butyl esters, chromium(VI)-mediated oxidation and radical...