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Spring 2019
Cancer remains a challenging disease to tackle. The heterogeneity and evolution of the disease necessitates the development of diverse approaches to treat cancer. In this thesis, two different approaches have been undertaken to address this issue. The first aim was to activate the master tumor...
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Functional Assessment on the Differential Effect of Mutant p53-Plakoglobin Interaction in Carcinoma Cells
DownloadSpring 2023
p53 transcriptional factor and tumor suppressor protein is mutated in over 50% of all cancers and most metastatic tumors. Majority of p53 mutations are single missense mutation and occur in the DNA-binding domain (DBD). The six most common missense mutations in the p53 DBD are known as “hot...
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Fall 2018
Chronic exposure to arsenic from groundwater is one of the greatest public health concerns in the world, putting over 170 million people at risk of arsenic-related diseases, including cancer, diabetes, and cardiovascular disease. Although our understanding of the mechanisms by which arsenic...
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Molecular Characterization of the Tumor and Metastasis Suppressor Activity of Plakoglobin in Mutant p53 Expressing Carcinoma Cells
DownloadFall 2018
Plakoglobin (γ-catenin) is an Armadillo protein family member and a paralog of β-catenin with similar dual cell-cell adhesion and signaling activities. These proteins interact with cadherins at the membrane and mediate cell-cell adhesion. In the cytoplasm, they interact with an array of cellular...