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Fall 2024

Wagner, Mitchell J.

Each year, roughly 100,000 Canadians are diagnosed with heart failure, a condition that can only be cured by heart transplantation. In recent years, there has been a plateau of heart transplantation volume, thought to be the result of declining donor sources and the bottleneck of short...

Fall 2020

Wang, Qian

Cellular responses to stress are an integral part of cardiovascular physiology and pathology, and endoplasmic reticulum (ER) stress is the key component in the development and progression of various heart diseases. However, the relative contribution of ER stress pathways to muscle damage and...

Spring 2019

Rawat, Sonia

Dramatic maturational changes occur in heart energy metabolism in the fetal to newborn transition, most predominantly marked by a decrease in glycolysis and an increase in fatty acid oxidation which then becomes the major energy providing substrate for the heart after birth. However, in the...

Spring 2012

Lam, Victoria Hol Mun

The surgical repair of congenital heart defects (CHDs) often requires a bloodless/motionless field achieved by arresting the neonatal heart and exposing it to a period of ischemia. Metabolic manipulation, such as suppression of fatty acid (FA) oxidation, improves post-ischemic functional recovery...

Fall 2015

Youssef, Nermeen Hosny Ibrahim

Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...

Spring 2019

Roczkowsky, Andrej

Matrix metalloproteinase-2 (MMP-2) is an intra- and extra-cellular protease which is activated during myocardial ischemia-reperfusion (IR) injury by reactive oxygen and nitrogen species, namely peroxynitrite. Upon its activation, MMP-2 impairs cardiac contractility by cleaving sarcomeric and...

Fall 2023

Holody, Claudia D

Introduction: Iron deficiency (ID) during gestation has been shown to alter growth and developmental trajectories, consequentially increasing the risk of long-term cardiovascular dysfunction in offspring. The heart becomes energetically dependent on mitochondria soon after birth and disturbances...