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Fall 2024
The modulation of resistance artery diameter is crucial for the regulation of tissue perfusion and systemic blood pressure. This is a multi-factorial process which necessitates the integrated activity of vascular endothelial and smooth muscle cells. A wide variety of endothelial and smooth muscle...
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Regulation of mesenteric resistance artery diameter by pharmacological modulators of KCa channels
DownloadFall 2018
Background: The diameter of resistance arteries, and thus, tissue perfusion and blood pressure, is tightly regulated through the integrated activity of endothelial and smooth muscle cells, and sympathetic nerves. The endothelium regulates the contractility of smooth muscle cells by releasing...
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Fall 2022
Background: This thesis encompasses two distinct projects. 1) von Willebrand factor (VWF) is a highly adhesive multimeric glycoprotein found in the Weibel-Palade bodies of endothelial cells and in ⍺-granules of megakaryocytes and platelets. At the site of vascular injury, VWF is essential for...