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Isoenzyme-Selective Inhibitors of Human Neuraminidases Reveal Distinct Effects on Cell Migration
Download2020-04-20
Howlader, Md. Amran, Guo, Tianlin, Chakraberty, Radhika, Cairo, Christopher W.
The human neuraminidase enzymes (NEU1, NEU2, NEU3, and NEU4) are a class of enzymes implicated in pathologies including cancer and diabetes. Several reports have linked neuraminidase activity to the regulation of cell migration in cancer cells. Using an in vitro cell migration assay on...
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Fall 2021
Glioblastoma (GBM) is the most common primary brain malignancy and has a dismal prognosis. Despite advanced therapies, including surgery and concurrent radiotherapy with temozolomide (TMZ), GBM patients only have a 14.6-month median survival time. This dismal outcome can be attributed to the...