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Spring 2019
Myt1 kinase performs several functions during Drosophila development. Myt1 has firstly been described as a regulator of the G2/M DNA damage checkpoint in the developing wing disc. In addition, Myt1 has been shown to regulate several aspects of male and female gametogenesis, while also...
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Mathematical modelling of the effect of low-dose radiation on the G2/M transition and the survival fraction via the ATM/Chk2 pathway
DownloadSpring 2020
Radiation therapy is an important component of cancer treatment. It consists of applying ionizing radiation to kill cells by damaging their DNA and reducing their ability to reproduce and survive. It is reasonable to think that more radiation causes more damage and kills more cells. However, in...
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Spring 2024
DNA double-strand breaks (DSBs) are considered the most deleterious DNA lesions. Unrepaired or incorrectly repaired DSBs can lead to cell cycle arrest, apoptosis, or over time, the accumulation of mutations and chromosomal abnormalities that give rise to cancer. The repair of DSBs by homologous...
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Spring 2019
In yeast, subtelomeric chromatin is silenced and positioned at the inner nuclear membrane (INM) through the interaction of proteins that comprise the heterotrimeric SIR complex with INM proteins. Telomeres reside primarily at the INM using partially redundant tethering mechanisms mediated by the...