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Fall 2022
Bacteriophages are highly abundant viruses that replicate within and effectively kill specific target bacterial hosts. The specificity of phages to their host relies on the presence of the correct cell surface receptor that is recognized by phage receptor binding proteins. These properties make...
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Engineering Stable Bacteriophage Dosage Forms Active Against Antibiotic-Resistant Bacteria for Respiratory Delivery and Food Safety Applications
DownloadFall 2019
The topic of this thesis is the engineering of stable bacteriophage dosage forms that are active against antibiotic-resistant bacteria for applications in respiratory delivery and food safety. Experimental methods and theoretical models are developed to test and understand the effects that...
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Insights into the role of the flagellar glycosylation system in Campylobacter jejuni phage-host interactions
DownloadFall 2018
Bacteriophages (phages) are the viruses that infect bacteria. Studying how phages interact with their hosts can inspire new ways of controlling bacterial pathogens and can highlight important facets of the biology of both organisms. Furthermore, phage-host characterization can inform exploitation...
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Isolation and Characterization of Lytic and Lysogenic Phages for Methanotrophic Bacterial Systems
DownloadFall 2019
Methanotrophic bacteria have the potential to act as a platform for several novel bio industrial processes, due to their capacity to convert methane, often from impure sources, into valuable products. These products can include, but are not limited to, isoprenoids for the development of bio-jet...
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Use of surfaces functionalized with phage tailspike proteins to capture and detect bacteria in biosensors and bioassays
DownloadFall 2010
The food safety and human diagnostics markets are in need of faster working, reliable, sensitive, specific, low cost bioassays and biosensors for bacterial detection. This thesis reports the use of P22 bacteriophage tailspike proteins (TSP) immobilized on silanized silicon surfaces, roughened at...