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Determination of Oligomeric State and Role of the Acidic C Terminal Tail of Vaccinia Virus I3 Single Stranded DNA Binding ProteinDownload
Single-stranded DNA (ssDNA) binding proteins (SSB) play a major role in DNA replication, recombination, and repair, by protecting ssDNA from nuclease attack and removing inhibitory secondary structure. Poxviruses are large double stranded DNA viruses that replicate within the cytoplasm of cells,...
Investigations into Differences between Vaccinia and Myxoma Virus Plaquing Properties Identifies Strategies for Increasing the Oncolytic Efficacy of Myxoma VirusDownload
Despite both being poxviruses, vaccinia (VACV) and myxoma (MYXV) form very different plaque types. VACV plaques are large and show a central clearing of cells, while MYXV plaques are smaller and result in a clumping of cells. VACV spread is promoted by the formation of an enveloped form of virus...
Natural Killer (NK) cells are a major part of the innate immune defence against viral infection and tumours. However, our understanding of how NK cells can be exploited for antiviral and antitumor therapy is still in its infancy. We are interested in the interplay between NK cells and Vaccinia...
Apoptosis serves as a powerful defense against damaged and unwanted cells. The family of Bcl-2 proteins plays a key role in the regulation of apoptosis at the mitochondria. Members of the Bcl-2 family include pro- and anti-apoptotic members that collectively determine the state of the cell....
The vaccinia virus N2 protein associates with karyopherins α2 and α4 and reduces the turnover rate of karyopherin α2Download
Due to their large genomes, poxviruses encode a number of enzymes, including a DNA polymerase and a DNA-dependent RNA polymerase, and therefore require few host gene factors for their replication. Several studies have shown several host nuclear factors are in fact recruited to viral sites of...
Recombination between co-infecting poxviruses provides an important mechanism for generating genetic diversity in the face of selection pressures. However, poxviruses replicate in membrane-bound enclosed cytoplasmic structures known as factories or virosomes that could impede DNA mixing between...