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Skip to Search Results- 13Multiple Sclerosis
- 2Experimental autoimmune encephalomyelitis
- 2Iron
- 2Neurotransmitters
- 2Phenelzine
- 15-HT
- 1Chadwick, Caylin Isabelle
- 1Deng, Xiaodan
- 1Deslauriers, Andre
- 1Elkady, Ahmed
- 1Frieser, Emma CG
- 1Jonzon, Alison Jill
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Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment
DownloadFall 2011
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified...
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Fall 2022
Calnexin is a type 1 integral endoplasmic reticulum (ER) membrane protein and molecular chaperone involved in the folding and quality control of membrane associated and secreted proteins. The ER luminal domain of calnexin is responsible for the chaperone function, whereas the C-terminal domain is...
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Chronic Pain in a Mouse Model of Multiple Sclerosis: Contributions of the Kappa Opioid System
DownloadFall 2021
The perception of pain is a multimodal experience that is encoded by regions of the central nervous system (CNS) that are involved in sensation, affect, and cognition. Chronic pain is not merely the persistence of pain, but a debilitating condition that is associated with neurochemical...
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Fall 2010
This study described the play experiences of daughters who were caregivers to their mothers with multiple sclerosis (MS). The experiences of four Canadian-Caucasian women aged 19-26 were captured using phenomenological methods of individual and focus group interviews, field notes, and artefacts....
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Development and Application of Quantitative Gradient-Echo MRI Techniques for Assessment of Iron and Myelin in the Multiple Sclerosis Brain
DownloadFall 2018
Multiple Sclerosis (MS) is a progressive autoimmune and neurodegenerative disease of the Central Nervous System that results in demyelination and neuronal/axonal loss. Along with clinical evaluation, Magnetic Resonance Imaging (MRI) is the gold standard modality for diagnosing and monitoring MS,...
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Fall 2013
Magnetic resonance imaging (MRI) is a valuable imaging modality and is commonplace in diagnosing, evaluating, and understanding the pathobiology of many neurological disorders. Current methods are helpful in the diagnosis of multiple sclerosis (MS) but fail to provide useful longitudinal...
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Endoplasmic reticulum stress induction by an endogenous retrovirus glycoprotein during neuroinflammation: regulation by a free radical scavenger
DownloadFall 2010
Endoplasmic reticulum (ER) stress is a homeostatic mechanism, which is utilized by cells to adapt to inter- and intra-cellular changes. There is a burgeoning literature showing that the human endogenous retroviral envelope glycoprotein, Syncyin-1, oxidative stress and reactive oxygen species...
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Fall 2011
Functional data analysis (FDA) is a fast-growing area in statistics with the aim of estimating a set of related functions or curves rather than focusing on a single entity, like estimating a point, as in classical statistics. FDA has a wide range of applications in different fields such as...
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Investigating the Effects of N2-Acetylphenelzine in the Sexes in Experimental Autoimmune Encephalomyelitis
DownloadFall 2017
Chronic pain is a highly prevalent symptom in Multiple Sclerosis (MS) and affects approximately half of patients at some stage of the disease. MS affects women more frequently than men and neuropathic pain is also reported as more severe, and frequent, in females with the disease. The underlying...