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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Clinical and Translational Studies Advancing Clinical Implementation of Stem Cell-Derived Islet Transplantation
DownloadSpring 2024
Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...
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Developing clinically translatable chimerism induction protocols in a stringent murine model
DownloadSpring 2020
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...