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Examining the origin of peripheral self-reactive T cells and the contribution of Gadd45beta to T cell selection events in the HYcd4 TCR transgenic mouse model
DownloadSpring 2014
Kelly, Stephanie Alicia Wilhelmina
Thymic negative selection is important for preventing self-reactive T cells from entering the circulation. However, some self-reactive T cell clones can escape negative selection and induce autoimmunity. The molecular pathways that regulate negative selection are currently unclear, but PD-1 and...
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