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Skip to Search Results- 1Anderson, Colin (Surgery and Medical Microbiology and Immunology)
- 1Baldwin, Troy (Department of Medical Microbiology and Immunology)
- 1Baldwin, Troy (Medical Microbiology and Immunology)
- 1Baldwin, Troy (Medical Microbiology and Immunology)
- 1Clemente-Casares, Xavier (Medical Microbiology and Immunology)
- 1Tsai, Sue (Medical Microbiology and Immunology)
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Characterizing tolerance in CD8 T cells in the absence of Bim-mediated clonal deletion to tissue restricted antigens
DownloadFall 2016
T cells are part of the adaptive immune system that eliminate pathogen-infected cells, but do not harm healthy cells. Precursor T cells, termed thymocytes, develop in the thymus where they randomly generate and express unique antigen specific T cell receptors (TCR) during the CD4+CD8+ double...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Fall 2019
T cells are a vital part of the adaptive immune system that function to eliminate foreign threats while remaining tolerant to healthy-self. During T cell development in the thymus, T cells are generated with various T cell receptor (TCR) specificities, such that they can respond to a near endless...
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T Cell Generation in a Lymphopenic Environment Generates Disease when the Thoracic Thymus is Eliminated; Augmentation by IL-7/Anti-IL-7 Complexes
DownloadSpring 2012
Cervical thymus functionally mimics the thoracic thymus in supporting T cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus generates an overall repertoire of T cells that are self-tolerant similar to the thoracic thymus. Mice...
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The role of obesity and insulin resistance in modulating immune cell function in cancer and liver disease
DownloadFall 2023
Obesity and associated insulin resistance (IR) represent a significant global health burden, and predispose individuals to develop various diseases, including cancer and liver diseases. Heightened inflammation during obesity can on the one hand exacerbate liver inflammation, while on the other,...