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Spring 2012
The association between stimulant drug use and the presence of a psychotic disorder raises questions about causation. Substance-induced psychosis may differ etiologically from schizophrenia despite similar phenotypic presentation. It is possible that stimulant drug users who develop symptoms of...
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Spring 2017
Cannabis use is a known risk factor for the development of psychotic disorders. Clinical and preclinical genetic studies provide growing evidence that genes related to dopamine signalling and neuroprotection, like COMT, are implicated in the cannabis-psychosis association. Considering the burden...
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Perineuronal nets and their role in cognitive impairment in central nervous system diseases
DownloadFall 2023
Perineuronal nets (PNNs) are organized components of the extracellular matrix that surround mature neurons of the central nervous system (CNS). These structures have neuroprotective properties for host cells, provide structural and functional stability, and have been implicated in brain functions...
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Phasic Electrodermal Activity in Schizophrenia: Skin Conductance Response in Unmedicated Schizophrenic Patients in Comparison to Normal Controls
DownloadSpring 2012
Stimulus-elicited (phasic) skin conductance responses (SCRs) to indifferent stimuli have often been employed to examine abnormalities in orienting (allocation of attention) in studies of schizophrenia. Most previous studies have examined phasic activity only during habituation paradigms....
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Spring 2016
Schizophrenia is a complex neurodevelopmental illness that often requires a combination of treatments to adequately control its symptoms. Despite the availability of several neuroleptic medications on the market, many patients with schizophrenia remain symptomatic. Research has shifted...