Phasic Electrodermal Activity in Schizophrenia: Skin Conductance Response in Unmedicated Schizophrenic Patients in Comparison to Normal Controls

  • Author / Creator
    Al-Ghamdi,Mohammad S
  • Stimulus-elicited (phasic) skin conductance responses (SCRs) to indifferent stimuli have often been employed to examine abnormalities in orienting (allocation of attention) in studies of schizophrenia. Most previous studies have examined phasic activity only during habituation paradigms. Interpretation of many studies is complicated because patients are medicated during testing. In this study cross-modal orienting response dishabituation paradigm was presented to 68 normal controls and 47 unmedicated schizophrenia patients while SCRs were recorded. Gender and laterality (bilateral recording in right-handed participants) were varied between- and within-subjects, respectively. Overall reactivity, and the following four discrete attentional effects were examined: habituation; reinstatement; “super reinstatement”; and dishabituation. For all participants, overall reactivity was lower for schizophrenics than for normal controls, as indexed by both amplitude- and response frequency-based measures. For SCR responders only, overall responsivity did not differ between groups. For SCR responders, habituation, reinstatement, and dishabituation were evident across groups. Super reinstatement approached significance.

  • Subjects / Keywords
  • Graduation date
    Spring 2012
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
  • Supervisor / co-supervisor and their department(s)
  • Examining committee members and their departments
    • Dursun,Serdar (Psychiatry)
    • Lind,John(Psychiatry)
    • Baker,Glen (Psychiatry)
    • Giuliani,Fabrizio (Neurology)