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Skip to Search Results- 1Brun, Miranda
- 1Clelland, Brett William
- 1Erickson, Timothy
- 1Gibeault, Rebecca L
- 1Yu, Kang
- 1Zhuo, Ran
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Spring 2015
Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...
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High resolution optical tweezers for single molecule studies of hierarchical folding in the pbuE riboswitch aptamer
DownloadSpring 2010
Riboswitches are gene regulatory elements found in messenger RNA that function by changing structure upon the binding of a ligand to an aptamer domain. Single adenine-binding pbuE riboswitch aptamer RNAs were unfolded and refolded co-transcriptionally using optical tweezers for single molecule...
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Investigation of an enhancer-based regulation of LILRB1 gene and the differential functions of LILRB1 variants in natural killer cells
DownloadFall 2020
Human cytomegalovirus (HCMV) causes severe disease in immunocompromised people such as transplant patients. NK cells are crucial in controlling HCMV whereas HCMV developed multiple strategies to evade NK cell surveillance. HCMV encodes a human MHC-I homolog called UL18 to target an inhibitory...
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
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Fall 2011
RNA polymerase III (RNAPIII) pre-initiation complexes at tRNA genes naturally cause replication fork pausing in the yeast Saccharomyces cerevisiae, and interference with replication is known to have deleterious effects on genome stability. It follows that repression of tRNA gene transcription...
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Fall 2017
Herpes simplex virus 1 (HSV-1) is a nuclear-replicating, double-stranded (ds) DNA virus. HSV-1 genes are expressed in a coordinate manner. The tegument protein VP16 first activates expression of the five immediate-early (IE) genes. Two IE proteins, ICP4 and ICP0, then activate early (E) and...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...