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Skip to Search Results- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
- 1Alvarado, Laura
- 1Amritpal Singh Bhullar
- 12Faculty of Rehabilitation Medicine
- 8Department of Oncology
- 6Faculty of Pharmacy and Pharmaceutical Sciences
- 5Centre for Neuroscience
- 5Department of Agricultural, Food, and Nutritional Science
- 3Department of Chemical and Materials Engineering
- 3Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 3McNeely, Margaret (Rehabilitation Medicine)
- 2Haennel, Bob (Faculty of Rehabilitation Medicine)
- 2Hebert, Jacqueline (Medicine)
- 2Uludag, Hasan (Chemical and Materials Engineering)
- 1Aalto, Daniel (Rehabilitation Medicine)
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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A Multi-perspective Concept Mapping Study of Head and Neck Cancer Treatment Outcome Priorities
DownloadFall 2020
Background Head and neck cancer treatments have been showing promising outcomes, yet they often have significant impact on patients. With an approximate 50% survival rate, individuals with a history of this type of cancer are living with long term challenges. With the increasing focus on...
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A Pilot Study Examining Feasibility of Perioperative Rehabilitation for Inguinal Hernia Repair Surgery
DownloadSpring 2023
Introduction: Despite the relative simplicity and high frequency of inguinal hernia repair (IHR) surgery, there is little research investigating pre- or post-operative exercise and education in this population. Recommendations regarding perioperative physical activity are inconsistent and largely...
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A pilot study investigating arm and leg FES-assisted cycling as an intervention for improving ambulation after Incomplete Spinal Cord Injury
DownloadSpring 2013
People with incomplete spinal cord injury (iSCI) have the potential for recovering walking through plasticity-induced changes in the remaining neural circuitry. Current rehabilitation for walking attempts to induce such changes by providing relevant sensory inputs and motor commands through...
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Spring 2013
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...
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Fall 2015
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
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Adaptive and Autonomous Switching: Shared Control of Powered Prosthetic Arms Using Reinforcement Learning
DownloadFall 2016
Powered prosthetic arms with numerous controllable functions (i.e., grip patterns or movable joints) can be challenging to operate. Gated control---a common control method for myoelectric arms and other human-machine interfaces---allows users to select a function by switching through a static...
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Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancer
DownloadSpring 2017
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2009
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...