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Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate Shiga toxin and serum amyloid P component ternary complex formation.
Download2011
Mulvey, G. L., Bundle, D. R., Deng, Z., Armstrong, G. D., Sadowska, J .M., Paszkiewicz, E., Griener, T., Ahmed, M., Narain, R., Kitov, P. I.
Inhibition of AB(5)-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin's pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system....
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Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation
2014
Macauley, M. S., Cheng, T. Y., Moody, D. B., Paulson, J. C. , Kawasaki, N., Van Rhijn, I., Rillahan, C. D.
Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are activated by lipid Ags presented by myeloid dendritic cells (DCs), after which they generate antibacterial effector functions, including...