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Fall 2024
Viral diseases are a constant threat that have profound impact on global health, economics and societies. Understanding virus-host interactions is key for advancing our knowledge of viral replication and pathogenesis, and thus for the development of effective antiviral strategies to better...
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Discovery and Targeted Approaches for Comparative Label-Free Proteomic Quantification via Mass Spectrometry
DownloadSpring 2023
Over the last few decades, the field of proteomics has developed rapidly owing to advancements in genomic and transcriptomic technologies contributing to the compilation of vast quantities of protein sequence libraries. Proteomics, the study of global protein composition in a biological system,...
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Fall 2021
Caspases are a family of enzymes that regulate biological processes, such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the mitochondria, which leads to the activation of...
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Investigation of CD36-Induced Anti-Angiogenic Signalling Platform via Proximity Biotinylation
DownloadFall 2024
In response to hypoxic conditions, tumours secrete pro-angiogenic factors that stimulate the development of new blood vessels. Given the critical role of angiogenesis in tumour progression, therapies counteracting cancer neovascularization have been developed. However, clinical studies have shown...
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
DownloadFall 2023
Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...