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Skip to Search Results- 3Phosphatidylcholine
- 1Apoptosis
- 1CTP:phosphocholine cytidylyltransferase
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Characterization of Phosphatidylcholine Metabolism in Mouse Hepatocytes after Hepatectomy and in Primary Human Hepatocytes
DownloadSpring 2012
Phosphatidylcholine (PC) is the major component of mammalian membranes and the induction of PC biosynthesis has been shown to be an essential step in cell proliferation in various cell lines. In the liver, PC biosynthesis is regulated by two pathways: the CDP-choline and the...
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Insights into the role of CTP:phosphocholine cytidylyltransferase-alpha in hepatic lipid metabolism and cellular integrity
DownloadFall 2011
Lower levels of hepatic phosphatidylcholine (PC) are suggested to play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Mice lacking hepatic CTP:phosphocholine cytidylyltransferase-α (LCTα-/-), the regulatory enzyme in the CDP-choline pathway for PC biosynthesis, were fed a...
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Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase
DownloadSpring 2010
Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT...