This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results-
Spring 2022
Phage display libraries bearing natural amino acids are commonly used for discovering potential therapeutic macrocycles; however, direct application of those linear peptides often leads to poor pharmacokinetics, including low serum stability, lower cell membrane permeability, and rapid renal...
-
Spring 2016
Carbohydrates play vital roles in many disease pathologies, including inflammatory disease, cancer metastasis, autoimmune disease and pathogenic infection. Despite their significance and immense opportunity for pharmaceutical application, carbohydrate-derived drugs only constitute a relatively...
-
In vitro compartmentalization and deep sequencing enable discovery of functional cell-binding ligands by phage display
DownloadFall 2015
Phage display is a technique that accelerated the discovery of peptide and protein-based ligands to numerous targets in academia and industry. Many FDA-approved antibodies and peptides on the market have originated from phage display experiments. However, one of the main drawbacks to this...
-
Phage Display as a Combinatorial Chemistry Platform for Discovery of Chemical Structure-Activity Relationships
DownloadFall 2018
Optimization of chemical reactions, discovery of optimal substrates and determination of substrate scope involve exhaustive screening of conditions as well as measurements of rates and conversions for all series of structurally similar substrates. These systematic screenings used in reaction...
-
Phage Display Derived Fragment-based Discovery of Antigens for Antibodies associated with Mycobacterial Infections
DownloadSpring 2017
Tuberculosis (TB) remains a global health problem. Incorrect or missed serodiagnosis for TB, especially in resource-limited settings, is one of the main reasons for TB epidemics. Clinically, serological tests that use circulating antibodies are attractive because antibodies in serum are present...
-
Spring 2014
Seetharaman Srinivasan, Praveen Raj
Recent studies have reported high rates of Helicobacter pylori (H. pylori) infection and gastric disease in the remote community of Aklavik (NWT) as compared with urban centers in Alberta. Current therapies fail to eradicate 20-25% of H. pylori infections, which may be related to antimicrobial...