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Characterizing the mode of action of super long-acting beta2-adrenergic receptor agonists: A more effective therapeutic for Parkinson's disease.
DownloadFall 2016
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons in the Substantia nigra (SN) resulting in hypokinetic motor movements. The long-acting beta2-adrenergic receptor (β2-AR) agonist salmeterol has been shown to be neuroprotective in animal...
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Spinal and Supraspinal Control of Reflexes: In health, under general anesthesia, and in Parkinson's disease
DownloadFall 2016
Reflexes have been used extensively for over a century both in the clinic and laboratory as a tool to assess functional connectivity within the spinal cord. In order to support the co-ordinated movement of muscles, the reflex arc is continuously under the influence of numerous peripheral and...