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- 8Parkinson's disease
- 2intramembrane proteolysis
- 2rhomboid protease
- 1Adrenergic receptor
- 1Andrews, Jennifer C
- 1Arbabzada, Naik Bakht
- 1Chang, Di
- 1Lysyk, Laine R.
- 1Monika, .
- 1Ryder-Burbidge, Charlotte
- 2Centre for Neuroscience
- 1Department of Biochemistry
- 1Department of Medical Microbiology and Immunology
- 1Department of Surgery
- 1Faculty of Rehabilitation Medicine
Intramembrane proteolysis is the process by which membrane-embedded proteases cleave substrates that are also embedded within the lipid bilayer or lie near to the bilayer. Rhomboid intramembrane proteases are a ubiquitous superfamily of serine intramembrane proteases that play a role in a wide...
Characterizing the mode of action of super long-acting beta2-adrenergic receptor agonists: A more effective therapeutic for Parkinson's disease.Download
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons in the Substantia nigra (SN) resulting in hypokinetic motor movements. The long-acting beta2-adrenergic receptor (β2-AR) agonist salmeterol has been shown to be neuroprotective in animal...
BACKGROUND: Parkinson’s disease (PD) is a progressive, neurodegenerative disorder characterized by resting tremors, instability, slowness of movement and rigidity, generally accompanied by non-motor symptoms such as mood disturbance, fatigue, constipation, incontinence and sleep disorders. Any...
Mechanism of beta 2 adrenergic receptor (β2AR) agonist in regulation of inflammation in Parkinson’s diseaseDownload
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by degeneration of dopaminergic neurons (DA-neurons) which are primarily present within a region of the brain called as substantia nigra (SN). Several studies suggest that the etiology of the PD includes...
Quantitative Assessment of Gait and Balance Following Deep Brain Stimulation in Patients with Parkinson’s DiseaseDownload
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia and postural instability. Deep Brain Stimulation (DBS) targeting either the subthalamic nucleus (STN) or globus pallidus interna (GPi) is highly effective for treating the cardinal...
PINK1 (Phosphatase-Tensin homologue (PTEN)-induced putative kinase 1) is a protein kinase heavily involved in mitochondrial health and integrity. It has multiple domains: an N-terminal mitochondrial targeting sequence, a transmembrane domain, and a kinase domain. Some mutations, located...
Spinal and Supraspinal Control of Reflexes: In health, under general anesthesia, and in Parkinson's diseaseDownload
Reflexes have been used extensively for over a century both in the clinic and laboratory as a tool to assess functional connectivity within the spinal cord. In order to support the co-ordinated movement of muscles, the reflex arc is continuously under the influence of numerous peripheral and...
The objective of this study was to examine a group vocalization program consisting of vocal exercises and choral singing designed to improve the voices of people with idiopathic Parkinson’s disease (IPD). A single group pretest-posttest research design was used. A total of 28 people with IPD...