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Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux
DownloadSpring 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...
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Fall 2017
The tripeptide glutathione (GSH, γ-Glu-Cys-Gly) is the most abundant non-protein thiol in mammalian cells. The thiol group within the Cys residue forms a nucleophilic center and neutralizes electronegative charges conferring antioxidant activity to GSH. The addition of GSH to electrophiles can be...
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Spring 2013
The mitochondria associated membranes (MAMs) of the endoplasmic reticulum (ER) are the points of contact between the ER, which is the organelle responsible for lipid and secreted protein synthesis and calcium storage, and the mitochondria, which are organelles responsible for cellular energy...