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Investigations of interactions between membrane and PEI/siRNA nanoparticles and their implication for non-viral gene delivery
DownloadSpring 2021
Cell entry of polynucleotide-based therapeutic agents can be promoted by nanoparticle (NP) mediated delivery. This dissertation investigates membrane penetration of polynucleotide NPs, using mainly computational approaches, accompanied by some experiments. Major emphasis was placed on...
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Molecular Dynamics Simulations of Polyethylenimine Mediated Nucleic Acid Complexation with Implications for Non-viral Gene Delivery
DownloadSpring 2013
Gene therapy is a promising therapeutic technique that involves delivering nucleic acids into cells. Polycations have evolved into a major category of gene carriers. Polyethylenimine (PEI) is one of the most effective polycationic carriers. Furthermore, modifying PEI with certain lipophilic...