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Computational High Throughput Screening Targeting DNA Repair Proteins To Improve Cancer Therapy
DownloadSpring 2012
Developing a new drug is a complex, highly structured, and expensive task. The further a potential drug progresses in the development process, the more costly its failure becomes. Virtual screening (VS) is the initial stage of a drug discovery process. Its job is to screen large compound...
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Fall 2012
The protein p53 is a key regulator of cellular response to a wide variety of stresses. In cancerous cells inhibitory regulators of the p53 protein such as MDM2 and MDMX are often overexpressed. In silico techniques could be used to inform the selection of interactions to target with novel drug...