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Insights into the Role of Choline Kinase in Endochondral Bone Formation and Human Osteoblasts Function
DownloadSpring 2014
Choline kinase (CK) phosphorylates choline to phosphocholine (PCho) and is the first enzyme in the CDP-choline pathway that generates phosphatidylcholine (PC). CK has three isoforms (CKα1, CKα2 and CKβ) that are encoded by two genes, Chkα and Chkb. Inactivation of Chkα results in embryonic...
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Spring 2018
Forkhead Box O transcription factors play important roles in bone metabolism via defending against oxidative stress and apoptosis (Almeida, 2011; Ambrogini et al., 2010). FoxO3a is of special interest as it is the predominant isoform in bone cells (Ambrogini et al., 2010). In osteoblasts, the...
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Transcription Factor FOXC1 Deregulates BMP-SMAD Signalling During Osteoblast Differentiation
DownloadFall 2016
Skeletal development is a tightly regulated process that continues through adulthood in the form of bone remodeling. Many bones of the appendicular and axial skeleton develop using a cartilage intermediate in a process called endochondral ossification. The cranial and flat bones of the skeleton...