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- 3Fraser, Marion
- 3Villatoro, Valentin (Supervisor)
- 1Caddy, Jordan F
- 1Kassiri, Zamaneh
- 1Li, Zhuo
- 1Martignetti, John A.
- 4Medicine and Dentistry, Faculty of
- 3Graduate Studies and Research, Faculty of
- 3Graduate Studies and Research, Faculty of/Theses and Dissertations
- 3Medicine and Dentistry, Faculty of/Medical Laboratory Science, Division of
- 1Medicine and Dentistry, Faculty of/Journal Articles (Medicine and Dentistry)
Insights into the Role of Choline Kinase in Endochondral Bone Formation and Human Osteoblasts FunctionDownload
Choline kinase (CK) phosphorylates choline to phosphocholine (PCho) and is the first enzyme in the CDP-choline pathway that generates phosphatidylcholine (PC). CK has three isoforms (CKα1, CKα2 and CKβ) that are encoded by two genes, Chkα and Chkb. Inactivation of Chkα results in embryonic...
Multicentric osteolysis with nodulosis, arthritis, and cardiac defect syndrome: loss of MMP2 leads to increased apoptosis with alteration of apoptotic regulators and caspases and embryonic lethalityDownload
Inactivating mutations of matrix metalloproteinase 2 (MMP2) cause multicentric osteolysis with nodulosis and arthritis, one of a group of inherited osteolytic and arthritic disorders. We have previously shown that mice lacking Mmp2 share similar syndromic features with the human disorder, and at...
Forkhead Box O transcription factors play important roles in bone metabolism via defending against oxidative stress and apoptosis (Almeida, 2011; Ambrogini et al., 2010). FoxO3a is of special interest as it is the predominant isoform in bone cells (Ambrogini et al., 2010). In osteoblasts, the...
Skeletal development is a tightly regulated process that continues through adulthood in the form of bone remodeling. Many bones of the appendicular and axial skeleton develop using a cartilage intermediate in a process called endochondral ossification. The cranial and flat bones of the skeleton...