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Biosynthetic Studies of Resorcylic Acid Lactones, Hypothemycin, Radicicol, and Dehydrocurvularin
DownloadFall 2013
Fungal polyketides, a vast source for pharmaceutical industries, are biosynthesized by multifunctional iterative polyketide synthases (PKS). The biosynthesis employs complex programming rules, which are currently unresolved. To decode the programming rules, the biosynthesis of three polyketides,...
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...
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Fall 2019
Carboxylic acids are a ubiquitous class of molecules in the field of organic chemistry and represent versatile building blocks in synthetic chemistry. Methods that enable the formation of new carbon–carbon or carbon–heteroatom bonds from carboxylic acids via the extrusion of carbon dioxide can...
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Enantioenriched Cyclic Boronates as Versatile Building Blocks: Synthesis, Mechanism and Applications
DownloadSpring 2020
Since the discovery and development of the famed Suzuki-Miyaura cross-coupling reaction, organoboron compounds have gained increasing attention as small molecule building blocks in organic synthesis and drug discovery efforts. In this regard, enantioenriched alkyl boronic esters are ideal...
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Studies on C–F Activation and Radiofluorination Reactions: Interactions of Fluorine with Boron and Silicon Lewis Acids
DownloadFall 2022
Boron and silicon Lewis acids form strong bonds with fluorine. This ability facilitates a range of interesting reactivity. For example, small boron/silicon reagents are at the forefront of C-F activation, a field focused on cleaving one or more C-F bonds in organofluorine compounds. In addition...
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Synthesis of fragments of a polysaccharide from Nocardia nova for structural and biological studies
DownloadSpring 2020
Nocardia are gram-positive bacteria. Nocardia nova is one of the Nocardia species and can cause serious disease, particularly in immunocompromised patients. Rapid diagnosis of N. nova can be lifesaving. The cell wall of N. nova contains an unusual glucose-modified arabinogalactan polysaccharide...