Development of Metal-Catalyzed Decarboxylative Cross-Coupling Reactions

  • Author / Creator
    Moon, Patrick J.
  • Carboxylic acids are a ubiquitous class of molecules in the field of organic chemistry and represent versatile building blocks in synthetic chemistry. Methods that enable the formation of new carbon–carbon or carbon–heteroatom bonds from carboxylic acids via the extrusion of carbon dioxide can present complementary reactivity and chemoselectivity to alternative cross-coupling reactions that use preformed organometallics reagents. While most carboxylic acids are typically considered stable, several strategies have been developed to promote decarboxylation and subsequent functionalization. This thesis describes the development of new methods for the decarboxylative functionalization of aliphatic carboxylic acids, using Cu, Ir, and Pd-catalysis.

  • Subjects / Keywords
  • Graduation date
    Fall 2019
  • Type of Item
  • Degree
    Doctor of Philosophy
  • DOI
  • License
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