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Fall 2015
In rodents, Ly49s are prominent natural killer (NK) cell receptors that interact with peptide-bound class I major histocompatibility complex (MHC-I). This association generally induces inhibitory signals when MHC-I presents self-peptides, thus blocking NK cell activation against healthy cells....
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Implications of genetic diversity on expression of LILRB1 in Natural Killer cells and susceptibility to HCMV infection in transplant patients
DownloadFall 2016
Leukocyte Ig-like Receptor 1 (LILRB1) is an inhibitory receptor expressed on a number of immune cells. The expression profile on NK cells is variable between people, with a range of 25-80% of NK cells expressing LILRB1. We previously uncovered a correlation between genotype within the 5’ end of...
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Fall 2016
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
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Regulation of FasL expression, and delineation of differentiation states of cytotoxic lymphocytes
DownloadSpring 2015
CD8+ T cells are vital cytotoxic lymphocytes against intracellular pathogens and tumor cells. CD8+ T cells utilize a fast-acting degranulation of granzyme/perforin and slow-acting receptor:ligand, FasL:Fas, pathway of inducing target cell lysis. The importance of degranulation based target cell...
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Fall 2013
Natural killer (NK) cells are innate immune lymphocytes that provide protection against virus infection and transformation. The cytolytic activity of NK cells is controlled by the signaling of receptors that stimulate or inhibit activation. One such inhibitory receptor expressed on human NK cells...