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In rodents, Ly49s are prominent natural killer (NK) cell receptors that interact with peptide-bound class I major histocompatibility complex (MHC-I). This association generally induces inhibitory signals when MHC-I presents self-peptides, thus blocking NK cell activation against healthy cells....
Implications of genetic diversity on expression of LILRB1 in Natural Killer cells and susceptibility to HCMV infection in transplant patientsDownload
Leukocyte Ig-like Receptor 1 (LILRB1) is an inhibitory receptor expressed on a number of immune cells. The expression profile on NK cells is variable between people, with a range of 25-80% of NK cells expressing LILRB1. We previously uncovered a correlation between genotype within the 5’ end of...
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
CD8+ T cells are vital cytotoxic lymphocytes against intracellular pathogens and tumor cells. CD8+ T cells utilize a fast-acting degranulation of granzyme/perforin and slow-acting receptor:ligand, FasL:Fas, pathway of inducing target cell lysis. The importance of degranulation based target cell...