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The TOB (Topogenesis of Outer membrane β-barrel proteins) complex is composed of the core proteins Tob55 (Sam50), Tob37 (Sam37) and Tob38 (Sam35). The complex facilitates the insertion of all β-barrel and some α-helically anchored integral proteins into the mitochondrial outer membrane (MOM)....
Biogenesis of Porin of the Outer Mitochondrial Membrane Involves an Import Pathway via Receptors and the General Import Pore of the TOM ComplexDownload
Abstract: Porin, also termed the voltage-dependent anion channel, is the most abundant protein of the mitochondrial outer membrane. The process of import and assembly of the protein is known to be dependent on the surface receptor Tom20, but the requirement for other mitochondrial proteins...
Not Simply the Induction of Alternative Oxidase: The AOD2 and AOD5 Transcription Factors Play Roles in Regulation of Metabolism and Energy Production in Neurospora crassaDownload
Mitochondria are important organelles in most eukaryotic organisms as they supply the majority of the ATP needed for cellular functions. Although mitochondria contain their own DNA, the vast majority of mitochondrial proteins are encoded in the nucleus. Thus, when mitochondria experience stress...
Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranesDownload
Precursor proteins of the solute carrier family and of channel forming Tim components are imported into mitochondria in two main steps. First, they are translocated through the TOM complex in the outer membrane, a process assisted by the Tim9/Tim10 complex. They are passed on to the TIM22...
The role of YVH1, a dual specificity phosphatase, in the production of alternative oxidase in the filamentous fungus Neurospora crassaDownload
Alternative oxidase (AOX) is a single protein enzyme that carries electrons from ubiquinol to molecular oxygen. AOX is induced in many organisms, including Neurospora crassa, when the standard electron transport chain is blocked through various inhibitors or mutations. A knockout (KO) for a dual...