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Skip to Search Results- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Jamali , Fakhreddin (Faculty of Pharmacy & Pharmaceutical Sciences)
- 1Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Siraki, Arno (Pharmacy and Pharmaceutical Sciences)
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Major Side Effects of Nonsteroidal Anti-Inflammatory Drugs: Gastrointestinal and Cardiovascular Risks of Etodolac and Interaction of NSAIDs with Cardioprotective Effects of Acetylsalicylic Acid.
DownloadFall 2018
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are administered for their anti-inflammatory, analgesic, and antipyretic properties. Thus, NSAIDs are one of the most commonly prescribed group of medications to relieve pain and inflammation associated with inflammatory conditions such as rheumatoid...
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Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicity
DownloadFall 2019
Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...