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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of ArthritisDownload
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicityDownload
Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health AuthoritiesDownload
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...